One piece of evidence that preregistration can act as a strong corrective comes from, a registry of publicly and privately funded clinical studies involving human subjects. Before 2000, when the site was established, 57 percent of large clinical trials funded by the National Heart, Lung and Blood Institute showed a significant benefit of drugs or other intervention, according to a recent analysis published in the journal PLOS One. After the registry was put in place, only 2 percent of such trials found a clear benefit.